Statistical box-whisker plots of tumor radiomic heterogeneity features of all patients compared between time points for each modality. (A) mean, (B) quantiles, (C) coefficient of variation, (D) skewness, (E) kurtosis of FDG PET standardized uptake value (SUV), DCE MRI plateau signal intensity ratio (SI), and DW MRI apparent diffusion coefficient (ADC) tumor voxel distributions. Mean (open marker), median (line), inter-quartile range (box) and range (whisker) across the patient cohort are shown for each imaging modality. Distributions of radiomic features were compared between imaging time points for each modality using the Skillings-Mack non-parametric test. P values were adjusted for multiple comparisons: *p < 0.05, **p < 0.01, ***p < 0.001.