Statistical box-whisker plots of tumor radiomic heterogeneity features of all patients compared between modalities at each time point. (A) coefficient of variation, (B) skewness, (C) kurtosis of FDG PET standardized uptake value (SUV), DCE MRI plateau signal intensity ratio (SI), and DW MRI apparent diffusion coefficient (ADC) tumor voxel distributions. Mean (open marker), median (line), inter-quartile range (box) and range (whisker) across the patient cohort are shown for each time point. Distributions of radiomic features at the same time point were compared between modalities using the Skillings-Mack non-parametric test. P values were adjusted for multiple comparisons: *p < 0.05, **p < 0.01, ***p < 0.001.