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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Exp Hematol. 2018 Mar 6;61:26–35. doi: 10.1016/j.exphem.2018.02.004

Table 2.

Recently generated HSC-specific inducible Cre recombinase mouse strains

Gene Method HSC Labeling Initial labeling in other BM populations Labeled HSC observations Ref.
Fgd5 Knock-in: CreERT2 60% LSK CD150+ (tdTomato) Small (5–10%) fractions of progenitors, endothelial cells Not reported [34]
Pdzk1ip1 BAC Tg: CreERT2 32% LSK CD48− CD150+ (tdTomato) Small (<5%) fractions of progenitors Major contribution to steady-state hematopoiesis (CreERT2) [37]
Tek (Tie2) Knock-in: Mer-Cre-Mer Minor fractions (<1%) LSK CD48− CD150+ (YFP) 1–3 weeks after induction Very minor fractions (<0.1%) of progenitors, endothelial cells not reported Minimal contributions to steady-state hematopoiesis [46]
Vwf Knock-in: CreERT2-P2A-EGFP 12% LSK CD34− CD48− CD150+ (tdTomato) 2–3 weeks after induction Not reported Preferential contribution to steady-state production of platelets [32]