Figure 1.

Adaptive therapy in the laboratory and the clinic. A) Mice implanted with triple negative human breast cancer were treated with adaptive paclitaxel treatment. If the volume dips below 150 mm³, a treatment vacation occurs, if there is a 20% tumor volume decrease (or increase), there is a 50% dose decrease (or increase), and otherwise the dose remains the same (see (10) for details). B) Patients with metastatic castrate resistant prostate cancer are treated with abiraterone such that treatment is stopped if PSA falls below 50% of the original and resumes when the PSA exceeds the original value.