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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Cancer Res. 2018 Jan 30;78(8):2127–2139. doi: 10.1158/0008-5472.CAN-17-2649

Figure 6.

Figure 6

Comparing treatments when tumor cell phenotypes can drift. A) Comparing CT, AT1, and AT2 treatments using a tumor from a pre-growth normal distribution of s=80% and σs=25%. Dose schedules, population dynamics, and spatial layout at various time points are shown for each treatment. See the Supplement for animation (Movie 6). B) Trajectories for average sensitivity vs. average dose over time. C) Winning strategies, and D) Average dose for different initial tumor compositions. See Figure 4 caption for details on each panel.