Table 1.

Averaged mean cluster size, solubility, and hydrophobicity scales

Amino acid residues	Parameters
	MCS a	Individual amino acid solubilityb (g/kg)	Hydropathyc	Hydrophilicityd (kcal/mol)	Hydrophobicitye (kcal/mol)	Contribution to protein solubilityf (mg/mL)	Average number of monomersa
Ile	25.1	34.2	4.5	0.2	2.5	0.1	0.6
Leu	26.2	23.8	3.8	0.1	1.8	na	0.3
Val	22.6	88.0	4.2	0.4	1.5	na	1.2
Gln	24.4	42.0	− 3.5	11.8	− 0.3	4.7	1.2
Asn	19.0	25.1	− 3.5	12.1	− 0.2	15.4	3.9
Thr	12.0	90.6	− 0.7	7.3	0.4	na	5.4
Ser	6.2	250.0	− 0.8	7.5	− 0.3	4.6	9.0
Ala	3.4	166.9	1.8	0.5	0.5	na	13.7
Pro	2.6	1625	− 1.6	na	− 3.3	2.0	12.9
Asp	1.1	5.4	− 3.5	13.3	− 7.4	14.2	25.4
Glu	1.0	8.6	− 3.5	12.6	− 9.9	11.0	26.5
Arg	1.0	182.6	− 4.5	22.3	− 11.2	8.9	24.6
Lys	1.1	5.8	− 3.9	11.9	− 4.2	17.0	25.4
Phe	23.1	27.9	2.8	3.2	2.5	na	0.4
Tyr	21.8	0.5	− 1.3	8.5	2.3	na	1.4
Trp	24.8	13.2	− 0.9	8.3	3.4	na	0.7
His	25.1	43.5	− 3.2	12.6	0.5	0.9	0.5
Met	24.8	56.0	1.9	3.9	1.3	na	0.7

^aMCS values are the mean cluster sizes. MSCs and the number of monomers averaged over the last 10 ns of simulation are reported in Kuroda et al. (2016).

^bLide ed, (2009)

^cKyte and Doolittle (1982)

^dWolfenden et al. (1981)

^eNozaki and Tanford (1971)

^fIslam et al. (2012)