Table 3.
Uni- and multi-variate cox regression analysis of risk factors associated with relapse free survival
| Univariable analysis | HR | 95% CI | p value | Multivariable analysis | HR | 95% CI | p value |
|---|---|---|---|---|---|---|---|
| Age, years | 0.93 | 0.89–0.97 | 0.001 | Age, years | 0.93 | 0.89–0.97 | 0.002 |
| Escalation to second line: no | 1 | Reference category | Escalation to second line: no | 1 | Reference category | ||
| Yes vs no | 3.31 | 1.56–7.04 | 0.002 | Yes vs no | 2.7 | 1.18–6.18 | 0.018 |
| PDGF groups: not detected PDGF | 1 | Reference category | PDGF category: not detected PDGF | 1 | Reference category | ||
| Medium PDGF vs not detected PDGF | 0.5 | 0.20–1.21 | 0.124 | Medium PDGF vs not detected PDGF | 0.28 | 0.10–0.79 | 0.017 |
| High PDGF vs not detected PDGF | 0.36 | 0.14–0.92 | 0.033 | PDGF vs not detected PDGF | 0.33 | 0.13–0.89 | 0.029 |
| MRI progression: no | 1 | Reference category | Not included in the multivariable final Cox regression model | ||||
| Yes vs no | 2.19 | 1.03–4.64 | 0.041 | ||||
| Sex: Male | 1 | Reference category | |||||
| Female vs male | 1 | 0.46–2.20 | 0.996 | ||||
| Disease duration, months | 0.95 | 0.77–1.19 | 0.667 | ||||
| IL-12 | 0.99 | 0.99–1.00 | 0.137 | ||||
| GMCSF | 1 | 0.99–1.01 | 0.908 | ||||
| FGF basic | 0.99 | 0.95–1.03 | 0.555 | ||||
| GCSF | 1.00 | 0.99–1.00 | 0.508 | ||||
| IL-10 | 0.99 | 0.98–1.01 | 0.328 | ||||