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Effects and mechanisms of IL-37 in cardiovascular disease.
| Diseases | Model | Effect | Mechanism | Reference |
|---|---|---|---|---|
| Atherosclerosis | ApoE-deficient diabetic mice | Attenuate vascular calcification and atherosclerosis | ↑OPG ↓ALP ↓BMP-2 ↓TNF-α ↓IL-18 ↑IL-10 |
[81] |
| Acute myocardial infarction | Mice of acute myocardial infarction | Improve myocardial infarction mice cardiac function | ↓MPO ↓NF-κB signaling | [84] |
OPG: osteoprotegerin. ↑: upregulate. ↓: downregulate.
