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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Acta Biomater. 2018 Mar 7;71:444–459. doi: 10.1016/j.actbio.2018.02.037

Table 3.

Functional classification of proteins, as defined by GO classification, that are altered in NTM50 cells cultured on either GTM or NTM ECM by at least 2-fold.

Proteins downregulated in NTM50 cells on GTM vs NTM ECM
Category Gene
Cell-cell adhesion LIMA1, HDLBP, KIF5B, PDLIM5, IQGAP1, EIF4G1, RPS26, ATIC, RARS, SND1, LRRC59, USO1, FASN, SPTBN1, CNN2, DBN1, EMD, AHNAK, SPTAN1
Translational initiation EIF4G1, EIF6, RPS26, RPL32, RPS17, RPS9, RPLP2, RPL4, RPS24
ER to Golgi vesicle-mediated transport SEC23A, SEC31A, COPG1, USO1, SEC22B, SPTBN1, DYNC1H1, SPTAN1
Translation WARS, RPS26, RPL32, RPS17, RRBP1, RPS9, RPLP2, RPL4, RPS24
Regulation of cellular amino acid metabolic process PSMA2, PSMD14, PSME2, PSMD1, NQO1
Regulation of mRNA stability PSMA2, EIF4G1, PSMD14, PSME2, PSMD1, HSPB1
Wnt signaling pathway, planar cell polarity pathway PSMA2, AP2B1, PSMD14, PSME2, PSMD1
Negative regulation of canonical Wnt signaling pathway PSMA2, DAB2, PSMD14, PSME2, PSMD1
MAPK cascade PSMA2, PSMD14, PSME2, PSMD1, SPTBN1, SPTAN1
Negative regulation of apoptotic process DAB2, SQSTM1, DDB1, HSPB1, GLO1, NQO1, NCL
Positive regulation of phagocytosis C3, PTX3, AHSG
Positive regulation of ERK1 and ERK2 cascade HMGB1, CD44, C3, CTGF
Cell adhesion CD44, CTGF, IGFBP7, MFGE8, MYH10
Hyaluronan metabolic process ITIH2, ITIH3
Positive regulation of collagen biosynthetic process CTGF, F2
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process HMGB1, CTGF
SMAD protein signal transduction AFP, GDF15
Positive regulation of JNK cascade HMGB1, CTGF
Inflammatory response HMGB1, C3, PTX3