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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Colloid Interface Sci. 2018 Feb 20;521:261–279. doi: 10.1016/j.jcis.2018.02.053

Figure 6.

Figure 6

(A) The ability of IGF to increase cell survival under serum-free conditions was studied at increasing concentrations of IGF—values of 200 ng/mL were optimal and significantly (p<0.001) increased viability 25% relative to untreated cells. (B) The release kinetics of IGF from the MSNs showed sustained release up to 48 hours. Here, red triangles are the percent of total release (right axis) and the black diamonds are absolute fluorescence from free IGF. (C) Sustained release of (IGF) from porous MSNs increases cell survival under serum-free media challenge as studied with MTS assay. The * indicates that the IGF-NPs had a statistically significant increase in viability versus incomplete media (p<0.05) and free IGF (p<0.05). IGF: Free IGF; BSA: Bovine Serum Albumin Control; MSNs/IGF: MSNs loaded with IGF; ICM: Incomplete Media (serum-free); CM: Complete Media. Error bars represent the standard error. Reproduced with permission113.