Figure 9. The effect of blocking IP₃Rs on USMC Ca²⁺ waves.

Aa and b, representative ST maps showing the effect of 100 μm 2‐APB on Ca²⁺ transient firing in USMCs. Ba–d, summary data showing the effect of 100 μm 2‐APB on USMC Ca²⁺ transient frequency (a), amplitude (b), duration (c) and spatial spread (d) (c = 19, n = 6). Ca and b, representative ST maps showing the effect of 1 μm xestospongin C (XeC) on Ca²⁺ transient firing in USMCs. Da–d, summary data showing the effect of XeC on USMC Ca²⁺ transient frequency (a), amplitude (b), duration (c) and spatial spread (d) (c = 20, n = 5). ns, not significant, ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001.