Table 1.
Study-level and participant-level characteristics of the contributing data sources
| ERFC | EPIC-CVD | UK Biobank | Participants with resurveys of alcohol consumption | ||
|---|---|---|---|---|---|
| Study level characteristics | |||||
| Location | 81 studies in 19 countries | 22 centres in 10 European countries | England, Scotland, and Wales | 37 studies in 15 countries | |
| Years of recruitment | 1964–2008 | 1990–2002 | 2006–10 | 1964–2010 | |
| Year of most recent endpoint follow-up | 2013 | 2009 | 2016 | 2016 | |
| Participant level characteristics | |||||
| Total participants | 356 819 | 30 702 | 358 833 | 89 499 | |
| Known current drinkers at baseline | 247 504 | 26 036 | 326 372 | 71 011 | |
| Weekly baseline alcohol consumption in current drinkers | |||||
| >0–≤25 g per week | 53 418 (22%) | 7906 (30%) | 39 641 (12%) | 12 301 (17% [11 g/week vs 36 g/week]‡) | |
| >25–≤50 g per week | 33 953 (14%) | 3704 (14%) | 39 334 (12%) | 8365 (12% [38 g/week vs 56 g/week]‡) | |
| >50–≤75 g per week | 26 656 (11%) | 2748 (11%) | 42 907 (13%) | 7322 (10% [63 g/week vs 80 g/week]‡) | |
| >75–≤100 g per week | 16 557 (7%) | 2446 (9%) | 36 780 (11%) | 6394 (9% [87 g/week vs 98 g/week]‡) | |
| >100–≤150 g per week | 36 236 (15%) | 2602 (10%) | 55 815 (17%) | 10 051 (14% [126 g/week vs 126 g/week]‡) | |
| >150–≤250 g per week | 31 645 (13%) | 3090 (12%) | 60 025 (18%) | 12 255 (17% [193 g/week vs 173 g/week]‡) | |
| >250–≤350 g per week | 23 607 (10%) | 1744 (7%) | 26 669 (8%) | 6927 (10% [303 g/week vs 248 g/week]‡) | |
| ≥350 g per week | 25 432 (10%) | 1796 (7%) | 25 201 (8%) | 7396 (10% [515 g/week vs 354 g/week]‡) | |
| Baseline characteristics restricted to all current drinkers | |||||
| Alcohol consumption (g/week), median (5th–95th percentiles) | 87·7 (2·2–522·4) | 61·9 (2·6–404·0) | 103·9 (11·8–420·8) | 105·2 (6·0–482·8) | |
| Age (years) at baseline | 57·1 (8·7) | 55·0 (9·2) | 56·5 (8·0) | 55·3 (8·2) | |
| Sex | |||||
| Male | 162 685 (66%) | 13 508 (52%) | 157 809 (48%) | 44 360 (62%) | |
| Female | 84 819 (34%) | 12 528 (48%) | 168 563 (52%) | 26 651 (38%) | |
| Smoking status | |||||
| Not current | 161 037 (65%) | 17 608 (68%) | 293 182 (90%) | 50 930 (72%) | |
| Current | 86 467 (35%) | 8428 (32%) | 33 190 (10%) | 20 081 (28%) | |
| History of diabetes | |||||
| No | 237 685 (96%) | 24 875 (96%) | 315 090 (97%) | 68 159 (96%) | |
| Yes | 9819 (4%) | 1161 (4%) | 11 282 (3%) | 2852 (4%) | |
| BMI, kg/m2 | 26·1 (3·8) | 26·4 (4·1) | 27·0 (4·4) | 26·1 (3·8) | |
| HDL-C, mmol/L | 1·40 (0·41) | 1·40 (0·42) | Not available* | 1·41 (0·41) | |
| Total cholesterol, mmol/L | 5·80 (1·17) | 6·11 (1·16) | Not available* | 5·78 (1·08) | |
| Systolic blood pressure, mm Hg | 136·5 (19·0) | 138·4 (21·3) | 137·9 (18·5) | 134·6 (18·4) | |
| Major outcomes restricted to current drinkers | |||||
| All-cause mortality events | 32 813 | 784† | 6720 | 6912 | |
| All cardiovascular disease | 18 791 | 12 758 | 7469 | 11 597 | |
Data are n, n (%), or mean (SD), unless otherwise indicated. ERFC=Emerging Risk Factors Collaboration. EPIC-CVD=European Prospective Investigation into Cancer and Nutrition—Cardiovascular Disease. BMI=body-mass index. HDL-C=high-density-lipoprotein cholesterol.
*
At the time of analysis, measurements of HDL-C and total cholesterol were not available in the UK Biobank.
†
All-cause mortality events from EPIC derive only from the 13 670 participants in the random sub-cohort of EPIC-CVD, rather than from the entire EPIC prospective study.
‡
Mean consumption (g/week) at baseline vs resurvey.