FIGURE 2.

ImmunoPET/MR imaging of IPA using the humanized Aspergillus-specific tracer [⁶⁴Cu]NODAGA-hJF5. The images show coronal maximum intensity projections (MIP), magnetic resonance (MR) imaging, and fused positron emission tomography (PET)/MR images of uninfected mice (PBS control) and mice infected with A. fumigatus. In order to render animals neutropenic, they received an intraperitoneal injection of the antibody RB6-8C5 and, 24 h later, were injected with the pathogen and [⁶⁴Cu]NODAGA-hJF5 tracer, according to the experimental procedure shown in Figure 1. Forty-eight hours after injection with the pathogen and humanized tracer, PET/MR imaging shows specific accumulation of the tracer in A. fumigatus-infected lung tissues. Image courtesy of MATHIAS Consortium.