Figure 1.

Inhibition of mammalian target of rapamycin complex 1, or its downstream target S6 kinase, rescues novel object recognition (NOR) memory in a mouse model of Parkinson’s disease. NOR test performance in control (Sham) mice treated with vehicle (n = 16), and Lesion mice treated with vehicle (n = 12), rapamycin (Lesion Rapa, n = 16), or PF-4708671 (Lesion PF, n = 8). (A) Representative traces of mice performing the NOR test. Triangles indicate the head position during the test (in black) and during exploratory behavior (in red). (B) Time spent exploring the familiar (Fam) or novel (Nov) object over a 5 min test. Data are expressed as percent of total exploration time and represented as mean ± SEM. **** p = 0.0001, *** p = 0.0003, and ** p = 0.003 vs. Fam within groups (two-way ANOVA followed by Fisher’s post hoc comparison).