Figure 6.

The effect of MRS 2500 on basal activity and EFS-evoked inhibitory effects on Ca²⁺ responses. (A) Representative ST map showing lack of effects of MRS 2500 (1 μM) on basal Ca²⁺ transients in ICC-DMP. (B) Summary data showing the effects of MRS 2500 (1 μM) on basal Ca²⁺ transient activity in ICC-DMP. Neither frequency (i), amplitude (ii), duration (iii), or spatial spread (iv) were affected by MRS2500 (n = 5; c = 10; ns = P > 0.05). (C,D) Representative ST maps showing the effects of MRS 2500 (1 μM) on Ca²⁺ transients during EFS (10 Hz for 5 s; indicated by the red line and dotted white box in ST maps). (E) Summary data showing the lack of effects of MRS 2500 (1 μM) on the inhibition of Ca²⁺ transients during the first 2 s of EFS: frequency (i), amplitude (ii), duration (iii), and spatial spread (iv) in ICC-DMP during control conditions (pre-EFS), and within the first 2 s of sustained EFS (n = 5, c = 6). ns = P > 0.05.