Table 3.

Significantly changed metabolites in M. nipponense hepatopancreas between the control group and the 24-h hypoxia group.

Peak	VIPa	P-valueb	FCc	LOG FCd	Metabolic pathways
Valine	1.44	0.01	0.26	−1.94	Amino metabolism
Citrulline 1	1.14	0.04	1.73	0.79	Amino metabolism
Cholesterol	2.53	8.2246E-09	4.49	2.17	Lipid metabolism
Uric acid	1.78	0.01	1.73	0.79	Purine metabolism
Succinic acid	2.14	0.04	2.0812E-05	−15.55	Energy metabolism
Citric acid	1.85	0.02	2.2245E-05	−15.46	Energy metabolism
Lysine	2.80	2.6343E-06	3.1941E-06	−18.26	Amino metabolism
Linoleic acid	1.52	0.03	0.63	−0.67	Lipid metabolism
Taurine	2.44	0.00	2.2863E-05	−15.42	Amino metabolism
Choline	1.23	0.04	0.16	−2.43	Amino metabolism
Pyruvic acid	1.38	0.01	4.11	2.04	Energy metabolism
Fumaric acid	2.21	2.3034E-05	2.73	1.45	Energy metabolism
Malic acid	1.15	0.03	0.16	−2.68	Energy metabolism
Isoleucine	1.85	0.02	0.39	−1.35	Amino metabolism
Lactose	1.18	0.05	4.24	2.08	Energy metabolism
Alanine	1.04	0.04	0.29	−1.76	Amino metabolism
Leucine	1.22	0.01	0.45	−1.15	Amino metabolism
Lactic acid	2.47	0.00	11833.791	13.53	Energy metabolism
Adenine	1.45	0.00	0.23	−2.13	Amino metabolism
2-hydroxybutanoic acid	1.37	0.04	0.40	−1.33	Glutathione synthesis

^aVariable importance in the projection (VIP) was acquired from the OPLS-DA model with a threshold of 1.0.

^bP-values were calculated from two-tailed Student's t-tests.

^cFC: fold change between 24-h hypoxia treatment and the control group.

^dPositive values indicate higher levels in the 24-h hypoxia group than in the control group, negative values indicate lower levels in the 24-h hypoxia group than in the control group.