Table 4.

Significantly changed metabolites in M. nipponense hepatopancreas between the control group and the 24-h hypoxia followed by 6-h reoxygenation group.

Peak	VIPa	P-valueb	FCc	LOG FCd	Metabolic pathways
Alanine	2.20	1.6326E-05	2.97	1.57	Amino metabolism
Sarcosine	1.76	0.01	2.39	1.26	Energy metabolism
Galactosamine	2.05	0.03	3.14	1.65	Glycometabolism
Lactic acid	2.16	6.0506E-05	2.57	1.36	Energy metabolism
Glycine 2	1.51	0.03	0.76	−0.40	Amino metabolism
Glutamate	2.14	0.00	2.08	1.05	Amino metabolism
Succinate acid	1.56	0.02	1.34	0.42	Energy metabolism
Citric acid	1.67	0.01	1.56	0.64	Energy metabolism
Lysine	1.20	0.02	0.58	−0.78	Amino metabolism
Linoleic acid	1.79	0.02	2.46	1.30	Lipid metabolism
Ribose	1.42	0.02	3.17	1.66	Nucleic metabolism
Methionine	1.80	0.02	0.07	−3.83	Amino metabolism
Allose	2.30	1.2542E-05	1.64	0.72	Glycometabolism
N-ethylmaleamic acid	2.24	4.8838E-05	1.64	0.71	Glutathione synthesis
Allo-inositol	2.10	0.01	2906.92	11.51	Glycometabolism
Isoleucine	1.28	0.01	0.42	−1.26	Amino metabolism
Leucine	1.48	0.025	0.37	−1.42	Amino metabolism
Glucose	2.67	0.00	29830.06	14.86	Energy metabolism
Lactone	1.49	0.04	574.16	9.17	Energy metabolism
Pyroglutamic acid	1.47	0.02	3.40	1.76	Glutathione synthesis
Fumaric acid	1.45	0.00	3.90	1.96	Energy metabolism
Malic acid	1.56	0.03	2.29	1.19	Energy metabolism
Cysteine	1.60	0.01	1.43	0.52	Energy metabolism
Myo-inositol	1.73	0.02	2426.09	11.24	Glycometabolism
2-hydroxybutanoic acid	1.55	0.02	1.46	0.55	Glutathione synthesis

^aVariable importance in the projection (VIP) was acquired from the OPLS-DA model with a threshold of 1.0.

^bP-values were calculated from two-tailed Student's t-tests.

^cFC: fold change between 6-h reoxygenation treatment group and the control group.

^dPositive values indicate higher levels in the 6-h reoxygenation treatment group than in the control group, negative values indicate lower levels in the 6-h reoxygenation treatment group than in the control group.