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. 2018 Apr 9;9:156. doi: 10.3389/fendo.2018.00156

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Copyright © 2018 Ponti, Farinetti, Marraudino, Panzica and Gotti.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic drawing summarizing adult neurogenesis in the V-SVZ/OB system. Adult neurogenesis is a multiple-step process, occurring in three different subregions: the ventricular-subventricular zone (V-SVZ), the rostral migratory stream (RMS), and the olfactory bulb (OB). Sex hormones reaching the lateral ventricle (LV) through the choroid plexus (CP) or blood vessels (BV) modulate each of those steps either directly on neurogenic lineage or indirectly through other component of the stem-cell niche or the parenchyma.