Table 2.
Summary of the hormonal regulations in the subventricular zone-olfactory bulb (V-SVZ-OB) system of adult male and female rodents.
| Hormone | Effect | Where | Reference | |
|---|---|---|---|---|
| Hormonal regulation of V-SVZ neurogenesis in adult females | ||||
| Mouse | Estrogen | ↓ Proliferation | V-SVZ | (39) |
| ↑ Proliferation (indirectly) | V-SVZ | (56, 57) | ||
| ↓ UV-induced apoptosis | In vitro | (34) | ||
| ↑ Stroke-induced neurogenesis | V-SVZ | (61, 69, 70) | ||
| ↓ Cell survival | MOB | (59) | ||
| ↓ Functionality | MOB | (60) | ||
| Mouse, rat | 5α-dihydrotestosterone | ↓ Expression AR | Choroid plexus | (51) |
| ↓ Cell survival | AOB | (29, 30, 66) | ||
| Hormonal regulation of V-SVZ neurogenesis in adult males | ||||
| Mouse | Castration | ↑ Proliferation | V-SVZ | (39) |
| ↓ Apoptosis | V-SVZ | (39) | ||
| Estrogen | ↓ UV-induced apoptosis | In vitro | (34) | |
| ↑ Stroke-induced neurogenesis | V-SVZ | (61, 69, 70) | ||
| Type 1 diabetes mouse model | ↑ Proliferation | V-SVZ | (71) | |
| ↓ Cell survival | AOB | (72) | ||
| Rat | 5α-dihydrotestosterone | ↓ Expression AR | Choroid plexus | (51) |
| castration | ↑ Expression ERβ | Choroid plexus | (51) | |
| ↓ Proliferation | V-SVZ | (41) | ||
| Estrogen | ↑ Proliferation | V-SVZ | (41) | |
| ↑ Stroke-induced neurogenesis | V-SVZ | (73, 74) | ||
| ↑ DCX + cells after stroke | V-SVZ | (73) | ||
| ↓ Cell death | V-SVZ | (74) | ||
| Testosterone | ↑ Proliferation | V-SVZ | (41) | |
| Progesterone | ↓ Proliferation | V-SVZ/OB | (75) | |
| ↓ Neurogenesis | RMS | (75) | ||