Figure 4.

The ANOVA plot for the 600 MHz urine ¹H NMR spectra of male FMO5 KO mice at week 60 age vs. the corresponding spectra of WT mice at week 15 age, showing positive peaks for those metabolite signals that are more intense at week 60 than at week 15, and negative peaks for those metabolite signals that are less intense. The signals are colour coded by the p-value from the ANOVA analysis. In this case a false discovery rate cut-off of 5% was used and the threshold p-value for significant difference was calculated as 0.0185, corresponding to those signals with colouring to the “red side” of light blue.