TABLE 1.

Demographic, pulmonary function and gas exchange parameters in noninvasive ventilation (NIV) group and no-NIV group

	NIV	No NIV	p-value
Patients	120	20
Age years	64.05±9.11	66.05±10.27	0.373
Males/females	56/64	6/14	0.164
Spinal/bulbar ALS onset	81/39	13/7	0.826
Time from ALS onset to NIV months	22.30±10.51	23.35±10.27	0.680
BMI kg·m−2	26.15±4.23	24.28±3.56	0.055
ALSFRS-R	29.01±7.84	28.94±7.22	0.973
NBS	26.75±10.33	18.84±8.30	0.001
No or moderate/severe bulbar dysfunction	105/15	14/6	0.052
FVC L	1.45±0.80	1.24±1.01	0.387
FVC % predicted	49.28±23.05	44.75±26.85	0.484
MIC L	1.96±0.95	1.58±1.21	0.240
PCF L·s−1	3.48±1.69	2.88±1.49	0.114
PCFMIC L·s−1	4.07±1.94	3.22±1.88	0.108
PCFMI−E L·s−1	3.70±1.07	3.26±0.64	0.090
PImax cmH2O	−42.37±22.82	−35.33±21.90	0.220
PEmax cmH2O	65.54±42.28	58.72±40.95	0.519
PaO2 mmHg	74.32±11.95	81.41±11.34	0.027
PaCO2 mmHg	50.34±8.68	45.52±7.42	0.023
HCO3− mmol·L−1	29.02±3.09	20.70±3.65	0.740
%sleepSpO2<90	30.96±28.74%	18.94±31.04%	0.162
SpO2mean	91.68±3.03%	92.62±2.84%	0.239
SpO2min	79.76±9.30%	86.93±6.48%	0.004

Data are presented as n or mean±sd unless otherwise stated. ALS: amyotrophic lateral sclerosis; ALSFRS-R: revised amyotrophic lateral sclerosis functional rating scale; BMI: body mass index; NBS: Norris scale bulbar subscore; FVC: forced vital capacity; MIC: maximum insufflation capacity; PCF: peak cough flow; PCF_MIC: manually assisted peak cough flow; PCF_MI-E: mechanically assisted peak cough flow; P_Imax: maximum inspiratory pressure; P_Emax: maximum expiratory pressure; P_aO2: arterial oxygen tension; P_aCO2: arterial carbon dioxide tension; %sleepS_pO2<90: time spent with oxygen saturation measured by pulse oximetry (S_pO2) <90%; S_pO2mean: mean S_pO2; S_pO2min: minimum S_pO2.