Table 1. Inhibitory Activity (IC₅₀, μM) of Rhodanines against Four MβLs in 50 mM Tris-HCl, pH 7.0^a.

	B1		B2	B3		B1		B2	B3
compd	NDM-1b	VIM-2b	ImiSc	L1b	compd	NDM-1b	VIM-2b	ImiSc	L1b
1a				0.32 ± 0.02	2b	0.69 ± 0.02			0.18 ± 0.02
1b	47 ± 1			1.7 ± 0.1	2c	14.3 ± 0.4			0.59 ± 0.02
1c				0.77 ± 0.09	2d	1.13 ± 0.06	0.92 ± 0.02		0.21 ± 0.02
1d			19.1 ± 0.6	0.16 ± 0.03	2e		1.9 ± 0.3	16.5 ± 0.3	0.12 ± 0.01
1e				0.37 ± 0.01	2f			6.9 ± 0.2	0.10 ± 0.01
1f		27.9 ± 0.3		0.28 ± 0.01	2g	12 ± 1		15.0 ± 0.3	0.31 ± 0.02
1g	25.1 ± 0.8			0.6 ± 0.1	2h	12.2 ± 0.9	3.6 ± 0.1	7.7 ± 0.9	0.070 ± 0.002
1h		15.3 ± 0.8		0.22 ± 0.06	2i	10.6 ± 0.8	3.5 ± 0.2	7.6 ± 0.2	0.030 ± 0.008
1i	21.5 ± 0.8	25.1 ± 0.4		0.080 ± 0.002	2j	8.4 ± 0.4	6.9 ± 0.2	3.6 ± 0.1	0.080 ± 0.003
1j	15.4 ± 0.9	14.4 ± 0.6		0.20 ± 0.02	2k	10.6 ± 0.5	2.36 ± 0.09	7.8 ± 0.5	0.070 ± 0.008
1k	14.3 ± 0.9	12.7 ± 0.9		0.11 ± 0.02	2l	1.31 ± 0.05	0.19 ± 0.03	3.0 ± 0.2	0.050 ± 0.003
1l	27.4 ± 0.4	16.8 ± 0.4		0.22 ± 0.01	2m	6.7 ± 0.2	3.9 ± 0.3	15.9 ± 0.8	0.020 ± 0.004
1m				0.10 ± 0.01	3a		4.7 ± 0.4		0.32 ± 0.01
2a	8.7 ± 0.9		18.3 ± 0.2	0.21 ± 0.01

^aBlank spaces represent percent inhibition under 50% at a concentration of 50 μM.

^bThe antibiotic used was cefazolin.

^cThe antibiotics used was imipenem.