Table 6. In Vitro and in Vivo Pharmacokinetics of 25.
| species | Rea | CL (mL/min/kg) | Vss (L/kg) | F (%) |
|---|---|---|---|---|
| human | <0.21 | |||
| dog | <0.21 | 4.3 | 1.7 | 93 |
| rat | 0.26 | 2.6 | 0.8 | 98 |
| mouse | 0.24 | 13.9 | 1.0 | 43 |
a
Re = ratio of extraction in microsomes; PK dose = 1 mg/kg.
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