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. 2018 Mar 26;9(4):312–317. doi: 10.1021/acsmedchemlett.7b00487

Scheme 1. Synthesis of Compounds 10–23.

Scheme 1

Reagents and conditions: (a) HATU, DIPEA, DMF, rt, overnight, yield 49–59%; (b) NaOH, MeOH, rt, 2 h, yield 71–85%; (c) CF3COOH, DCM, 40 °C, 3 h, yield 62–77%; (d) HATU, DIPEA, DMF, rt, overnight, yield 53–85%; (e) NH2OH-HCl, KOH, MeOH, rt, 2 h, yield 43–83%.