Table 2. Pharmacokinetic Profiles of Compound 10 in Sprague–Dawley Ratsa.
| compds | Cmax (ng/mL) | Tmax (h) | T1/2 (h) | AUC(0-inf) (ng/mL·h) | F (%) |
|---|---|---|---|---|---|
| 2 (Po) | 5560 ± 967 | 0.8 | 4.5 ± 0.8 | 30747 ± 785 | |
| 10 (Po) | 5765 ± 1276 | 2.0 | 3.4 ± 0.1 | 33534 ± 225 | 18 |
| 10 (Iv) | 12039 ± 1762 | 0.083 | 1.4 ± 0.05 | 3646 ± 201 |
Data are presented as mean ± SD.