Figure 4.

Aβ levels in tissues and culture media in long-term OHSC from old 3xTg-AD mice. Following 4-week culture, levels of Aβ42 from (A) lysed hippocampal slices and (B) culture media collected for 48 hr were measured by ELISA in young 3xTg-AD, old WT C57BL/6J and old 3xTg-AD mice. Each bar, mean±SE. ^**p<0.01, ^***p<0.001 by Bonferroni post-hoc analysis. Aβ: β-amyloid, AD: Alzheimer’s disease (model), WT: wild type.