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. 2018 Apr 9;9:707. doi: 10.3389/fimmu.2018.00707

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Copyright © 2018 Greaves, Peterson, Torres and Pelanda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B cell-specific expression of caMEK does not induce B cell activation, but increases serum Ig levels. (A–E) MFI levels of (A) CD86, (B) CD69, (C) CD44, (D) CD138, and (E) CD23 on splenic B220⁺ B cells from 3-83Igi, H-2^b mb1Cre and B220⁺GFP⁺ B cells R26-LSL-caMEK-GFP-mb1Cre mice. N = 9 total 3-83Igi,H-2^b-mb1Cre mice and N = 7 total 3-83Igi,H-2^b-R26-LSL-caMEK-GFP-mb1Cre mice, analyzed in four independent experiments. (F) Concentrations (μg/mL) of total IgM, IgG, IgE, and IgA in the sera of 3-83Igi,H-2^b-mb1Cre littermate controls (N = 7, open circles) and 3-83Igi,H-2^b-R26-LSL-caMEK-GFP-mb1Cre (N = 7, filled squares) mice. **P ≤ 0.01; NS, not significant.