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. 2018 Mar;13(3):484–491. doi: 10.4103/1673-5374.228732

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effect of acetyl-11-keto-β-boswellic acid (AKBA) on phospho-extracellular signal-regulated kinase 1 and 2 (p-ERK1/2) relative expression levels detected by western blot assay of injured nerve from the rat sciatic nerve injury model.

p-ERK1/2 expression was investigated in the rat sciatic nerve at 10, 20, and 30 days after surgery. Relative expression of p-ERK 1/2 was expressed by a ratio of the optical density values of P-ERK 1/2 to ERK 1/2. (A) PNI group: peripheral nerve injury (PNI) model only; (B) low-dose AKBA group: PNI model + 1.5 mg/kg AKBA for 30 days; (C) medium-dose AKBA group: PNI model + 3 mg/kg AKBA for 30 days; and (D) high-dose AKBA group: PNI model + 6 mg/kg AKBA for 30 days. Data were expressed as the mean ± SD and analyzed by t-test. *P < 0.05, **P < 0.01, vs. PNI group. d: Days.