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. 2018 Mar;13(3):549–555. doi: 10.4103/1673-5374.228761

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Morphological changes in Müller cells treated with Y-27632 and exposed to hypoxic or oxidative stress conditions.

(A–F) Morphological changes in Müller cells treated with 10 μM Y-27632 after 24 hours of hypoxia (original magnification: 40× in A–C and 100× in D–F). (A, D) Cellular morphologies in the control group: cells are often long spindle- or triangular-shaped. (B, E) Cellular morphologies in the CoCl2 group: the number of cells is reduced and the shape is irregular. (C, F) Cellular morphologies in the CoCl₂ + Y27632 group: cell number increases and shape improves compared with the CoCl₂ group. (G–L) Morphological changes in Müller cells treated with 10 μM Y-27632 after 24 hours of oxidative stress (original magnification: 40× in G–I and 100× in J–L). (G, I) Cellular morphologies in the control group. (H, K) Cellular morphologies in the H₂O₂ group. (I, L) Cellular morphologies in the H₂O₂ + Y27632 group. Arrows indicate Müller cells.