Table 4.
Association of the 7 variants at the APOA5 gene locus with lipid profiles in the Kuwaiti Cohort (n = 733).
| SNP | Lipid parameter | W/W | W/M | M/M | p-value | |||
|---|---|---|---|---|---|---|---|---|
| n | n | n | ||||||
| rs651821 | BMI | 386 | 27.15 ± 0.34 | 113 | 27.23 ± 0.56 | 12 | 26.92 ± 2.07 | 0.99 |
| TC | 385 | 4.89 ± 0.05 | 113 | 4.63 ± 0.08 | 12 | 4.97 ± 0.27 | 0.4 | |
| TG | 386 | 0.92 ± 0.04 | 113 | 0.97 ± 0.06 | 12 | 1.10 ± 0.18 | 0.15 | |
| VLDL | 379 | 0.39 ± 0.02 | 112 | 0.41 ± 0.03 | 12 | 0.46 ± 0.08 | 0.18 | |
| HDL | 372 | 1.2 ± 0.02 | 109 | 1.72 ± 0.03 | 11 | 1.16 ± 0.07 | 0.92 | |
| LDL | 371 | 3.08 ± 0.04 | 109 | 3.06 ± 0.07 | 11 | 3.42 ± 0.29 | 0.4 | |
| rs2072560 | BMI | 404 | 26.94 ± 0.34 | 97 | 26.94 ± 0.58 | 10 | 24.80 ± 1.33 | 0.68 |
| TC | 403 | 4.67 ± 0.05 | 97 | 4.69 ± 0.09 | 10 | 5 ± 0.31 | 0.28 | |
| TG | 404 | 0.92 ± 0.04 | 97 | 0.98 ± 0.06 | 10 | 1.10 ± 0.22 | 0.04* | |
| VLDL | 397 | 0.39 ± 0.02 | 96 | 0.41 ± 0.03 | 10 | 0.46 ± 0.10 | 0.04* | |
| HDL | 389 | 1.19 ± 0.02 | 94 | 1.18 ± 0.04 | 9 | 1.15 ± 0.08 | 0.93 | |
| LDL | 389 | 3.07 ± 0.04 | 94 | 3.09 ± 0.07 | 9 | 3.46 ± 0.35 | 0.25 | |
| rs3135506 | BMI | 447 | 27.05 ± 0.30 | 64 | 27.89 ± 0.93 | – | – | 0.39 |
| TC | 447 | 4.66 ± 0.04 | 63 | 4.81 ± 0.12 | – | – | 0.31 | |
| TG | 447 | 0.94 ± 0.03 | 64 | 0.93 ± 0.07 | – | – | 0.99 | |
| VLDL | 442 | 0.40 ± 0.02 | 61 | 0.38 ± 0.03 | – | – | 0.83 | |
| HDL | 431 | 1.18 ± 0.02 | 61 | 1.23 ± 0.06 | – | – | 0.34 | |
| LDL | 431 | 3.07 ± 0.04 | 61 | 3.16 ± 0.12 | – | – | 0.69 | |
| rs2266788 | BMI | 386 | 27.27 ± 0.34 | 113 | 26.98 ± 0.57 | 12 | 25.08 ± 1.13 | 0.77 |
| TC | 385 | 4.65 ± 0.05 | 113 | 4.77 ± 0.08 | 12 | 4.78 ± 0.26 | 0.24 | |
| TG | 386 | 0.92 ± 0.04 | 113 | 1.00 ± 0.06 | 12 | 0.99 ± 0.20 | 0.02* | |
| VLDL | 380 | 0.39 ± 0.02 | 111 | 0.42 ± 0.02 | 12 | 0.42 ± 0.09 | 0.03* | |
| HDL | 371 | 1.19 ± 0.02 | 110 | 1.20 ± 0.04 | 11 | 1.18 ± 0.07 | 0.87 | |
| LDL | 371 | 13.06 ± 0.04 | 110 | 3.13 ± 0.07 | 11 | 3.22 ± 0.34 | 0.38 | |
| Novel SNP 1 | BMI | 509 | 27.17 ± 0.29 | 2 | 25.35 ± 4.65 | – | – | 0.94 |
| TC | 509 | 27.17 ± 0.29 | 2 | 25.35 ± 4.65 | – | – | 0.75 | |
| TG | 509 | 0.94 ± 0.03 | 2 | 0.64 ± 0.26 | – | – | 0.98 | |
| VLDL | 501 | 0.40 ± 0.01 | 2 | 0.26 ± 0.11 | – | – | 0.93 | |
| HDL | 490 | 1.19 ± 0.02 | 2 | 1.21 ± 0.09 | – | – | 0.68 | |
| LDL | 490 | 3.08 ± 0.04 | 2 | 2.80 ± 0.60 | – | – | 0.83 | |
| Novel SNP 2 | BMI | 510 | 27.16 ± 0.29 | 1 | 28 ± 0.00 | – | – | 0.83 |
| TC | 509 | 4.68 ± 0.04 | 1 | 4.66 ± 0.00 | – | – | 0.99 | |
| TG | 510 | 0.94 ± 0.03 | 1 | 0.56 ± 0.00 | – | – | 0.68 | |
| VLDL | 502 | 0.40 ± 0.01 | 1 | 0.25 ± 0.00 | – | – | 0.81 | |
| HDL | 491 | 1.2 ± 0.02 | 1 | 0.89 ± 0.00 | – | – | 0.2 | |
| LDL | 491 | 3.08 ± 0.04 | 1 | 3.52 ± 0.00 | – | – | 0.48 | |
| rs662799** | BMI | 347 | 26.86 ± 0.33 | 140 | 27.80 ± 0.64 | 19 | 28.36 ± 1.18 | 0.26 |
| TC | 347 | 4.69 ± 0.05 | 140 | 4.61 ± 0.08 | 19 | 4.60 ± 0.22 | 0.32 | |
| TG | 347 | 0.97 ± 0.04 | 140 | 0.87 ± 0.05 | 19 | 0.79 ± 0.15 | 0.01* | |
| VLDL | 346 | 0.41 ± 0.02 | 138 | 0.37 ± 0.02 | 18 | 0.35 ± 0.07 | 0.03* | |
| HDL | 333 | 1.18 ± 0.02 | 135 | 1.22 ± 0.03 | 18 | 1.25 ± 0.10 | 0.15 | |
| LDL | 333 | 3.10 ± 0.04 | 135 | 3.00 ± 0.07 | 18 | 3.00 ± 0.22 | 0.12 |
− W/W homozygous for common allele, W/M heterozygous for the minor allele, M/M homozygous for minor allele.
− Lipid levels data are shown as mean ± SEM for TC: total cholesterol; TG, triglycerides; HDL, High-Density Lipoprotein; LDL, Low-Density lipoprotein; VLDL, Very Low-Density Lipoprotein.
− p-values were derived from Kruskal-Wallis ANOVA with adjustment for sex, age and BMI assuming a co-dominant genetic model.
*
Significant values (p < 0.05) are highlighted.
**
Analyzed in a sample of 549 as the remaining samples of the cohort were not genotyped.