Table 5.
Results of multivariate analysis of the APOA5 rs2072560, rs2266788 and rs662799 with triglycerides (TG) and Very Low-Density Lipoprotein (VLDL) levels in the cohort (n = 733).
| Variable | OR | 95% C.I. | p-value | |
|---|---|---|---|---|
| TG | ||||
| (RF allele: G) | rs2072560 G/A | 1.09 | (0.98–1.22) | 0.12 |
| rs2072560 A/A | 1.42 | (1.03–1.95) | 0.03* | |
| Sex (M) | 1.27 | (1.16–1.39) | 2.11E-07* | |
| Age | 1.01 | (1.01–1.02) | 2.81E-15* | |
| BMI | 1.02 | (1.02–1.03) | 2.44E-11* | |
| (RF allele: T) | rs2266788 T/C | 1.15 | (1.03–1.27) | 0.01* |
| rs2266788 C/C | 1.24 | (0.93–1.67) | 0.13 | |
| Sex (M) | 1.28 | (1.17–1.40) | 1.26E-07* | |
| Age | 1.01 | (1.01–1.02) | 2.23E-15* | |
| BMI | 1.02 | (1.02–1.03) | 2.88E-11* | |
| (RF allele: T) | rs662799C/T | 0.9 | (0.82–1) | 0.05 |
| rs662799T/T | 0.73 | (0.58–0.92) | 0.01* | |
| Sex (M) | 1.27 | (1.16–1.39) | 4.89E-07* | |
| Age | 1.02 | (1.01–1.02) | 4.0E-15* | |
| BMI | 1.02 | (1.02–1.03) | 1.29E-11* | |
| VLDL | ||||
| (RF allele: G) | rs2072560 G/A | 1.09 | (0.98–1.23) | 0.11 |
| rs2072560 A/A | 1.42 | (1.03–1.97) | 0.03* | |
| Sex (M) | 1.27 | (1.15–1.39) | 1.02E-06* | |
| Age | 1.02 | (1.01–1.02) | < 2E-16* | |
| BMI | 1.02 | (1.02–1.03) | 2.22E-11* | |
| (RF allele: T) | rs2266788 T/C | 1.14 | (1.02–1.27) | 0.02* |
| rs2266788 C/C | 1.25 | (0.92–1.68) | 0.15 | |
| Sex (M) | 1.27 | (1.16–1.39) | 6.05E-07* | |
| Age | 1.02 | (1.01–1.02) | < 2E-16* | |
| BMI | 1.02 | (1.02–1.03) | 2.84E-11* | |
| (RF allele: C) | rs662799C/T | 0.9 | (0.81–1) | 0.05 |
| rs662799T/T | 0.78 | (0.61–1) | 0.05 | |
| Sex (M) | 1.27 | (1.15–1.39) | 9.73E-07* | |
| Age | 1.02 | (1.01–1.02) | <2E-16* | |
| BMI | 1.03 | (1.02–1.03) | 1.12E-11* | |
RF: Reference allele. The values represented include the odds ratio, confidence interval and p values as evaluated by multivariate logistic regression in 511 Kuwaiti individuals. It shows the mentioned variants to be a significant
(p < 0.05) independent predictive factor when controlling for age, sex and BMI for both TG and VLDL. Significant values (p < 0.05) are highlighted.