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. 2018 May;24(5):643–655. doi: 10.1261/rna.064881.117

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© 2018 Trontti et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 1. — Genomic location of miRNAs and SNP variation within high-confidence miRNA loci. (A) Number of miRNAs located within or outside of protein-coding genes. (B) Distribution of SNPs and average nucleotide divergence (π) across miRNA loci. (C) Number of miRNAs with SNPs between 36 inbred mouse strains in the seed, mature miRNA sequence excluding the seed, and pre-miRNA excluding the mature miRNA sequence. (D) Nucleotide divergence (π) in high-confidence miRNA loci, 1 kb of 5′ and 3′ flanking sequences, random protein-coding exons, and noncoding regions. Sixteen SNPs (in 16 miRNAs) were located in the seed region (nucleotides 2–8 from the 5′ start of the canonical mature miRNA), 65 (in 52 miRNAs) in the mature miRNA sequence excluding the seed region, and 159 (in 116 miRNAs) in the pre-miRNA sequence excluding the mature miRNA and the seed sequences. Mean and standard error of the mean is calculated over all miRNA loci. All groups differ significantly from each other, except 5′ and 3′ flanking sequences (Kruskal–Wallis test, π P < 2.2 × 10⁻¹⁶). (CDS) Coding sequence.