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. 2018 May;24(5):643–655. doi: 10.1261/rna.064881.117

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© 2018 Trontti et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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FIGURE 4. — Mature miRNAs are frequently edited. (A) Distribution and frequency of RNA–DNA mismatch positions in canonical mature miRNA and ±3 bases up- and downstream. Editing frequency and Shannon entropy, a measure of DNA diversity, were averaged over miRNAs with editing in the corresponding position. Editing frequencies correlated well with entropy (R² = 0.82), indicating that higher editing frequency is associated with greater diversity in the edited position. (B) Editing frequency of miRNAs. (C) Distribution of RNA–DNA mismatches separately for the seed region, anchor sequence, and 3′-tail.