Skip to main content
. 2018 Mar 1;32(5-6):389–401. doi: 10.1101/gad.307132.117

Figure 3.

Figure 3.

Evolutionary conservation and sufficiency of an ETS2,3-like pair for MHE repression. (A) Phylogenetic tree (adapted from Gramates et al. 2017) and schematic representation of MHE ETS sites in eight different Drosophila species; light gray indicates species whose sequences were not analyzed. Full MHE sequences, as identified by Hare et al. (2008), are in Supplemental Figure S2L. (B) The introduction of ectopic paired high-affinity ETS sites can restore effective repression to the MHEmut2,3 reporter. Error bars show SEM. Statistical significance after Bonferroni correction from either MHEWT, MHEmut2,3, or MHEmut2,3 strong9,8 (where relevant) is shown. (*) P < 0.05; (***) P < 0.001.