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. 2018 Jan 16;124(7):1358–1373. doi: 10.1002/cncr.31125

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© 2018 Foundation Medicine, Inc. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A) Distribution of the ERBB2/3 variants in 569 metastatic colorectal cancer (mCRC) cases. (B) Alterations most commonly observed in (Top) ERBB2 and (Bottom) ERBB3. Shown here are the extracellular (I‐IV), transmembrane (TM), and kinase (KD) domains of human epidermal growth factor receptor 2 (HER2) and HER3. Dark blue dots represent known activating missense alterations, whereas light blue dots are missense mutations suspected to be activating or recurrent in cancer. Green dots represent truncating frameshift alterations that are expected to remove a regulatory phosphorylation site from the C‐terminus of HER2. Amp indicates amplification; SV, short variants.