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. 2018 Jan 16;124(7):1358–1373. doi: 10.1002/cncr.31125

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© 2018 Foundation Medicine, Inc. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(A) Metastatic colorectal cancer to the liver in a 72‐year‐old woman whose tumor had progressed after 4 separate lines of chemotherapy. (B) Comprehensive genomic profiling revealed both ERBB2 (163 copies) and retinoic acid receptor alpha (RARA) (35 copies) amplification as well as multiple untargetable short variant genetic alterations. This tumor responded clinically for 6 months to a combination of trastuzumab and lapatinib, with a significant decrease in serum carcinoembryonic antigen levels.