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. 2018 Apr 5;9:112. doi: 10.3389/fpsyt.2018.00112

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Copyright © 2018 Robins, Chiang, Mores, Alongkronrusmee and van Rijn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic knockout (KO) of β-arrestin-2 reveals critical role of G_i/o signaling in reducing alcohol intake via dorsal striatal delta-opioid receptor activation. Cannula placement was verified for all animals included in behavioral analysis (A). C57BL/6 male, β-arrestin-2 KO mice (n = 12) were trained to consume 10% alcohol over the course of 3 weeks, during which they increased their alcohol intake (B) and alcohol preference (C). Vehicle saline (0.9%) infusion did not change alcohol intake, but both TAN-67 and SNC80 (10 µM) significantly decreased alcohol intake (D). Significance by repeated measures, multiple comparisons (Tukey) by two-way ANOVA, *p < 0.05 and **p < 0.01.