Figure 3.

Physiology of CMA. CMA participates in cellular quality control. CMA participates in (A) cellular quality control through the removal of damaged or abnormal proteins and in (B) cellular metabolism and energetics through recycling of the amino acids of the degraded proteins and by selectively degrading rate-limiting enzymes of lipid and glucose metabolism. C, timely degradation of specific proteins through CMA confers this pathway's regulatory function in multiple cellular processes. Some of these processes and the CMA substrates involved in these pathways are depicted.