Figure 5.

Unfolded proteins induce a subset of ER chaperones and folding enzymes. A, histograms showing UPRome coverage by MS with the respective percentage. B, correlation between mRNA log₂ fold-change (y axis) and protein log₂ fold-change (x axis) from GEP and LFQ-MS data, respectively, upon drug treatments for mRNA-protein pairs with a positive log₂ fold-change values. C, same as B for expression of unfolded proteins. D, interaction network (string-db.org/)³ (69) of identified core UPR genes induced by the expression of unfolded proteins. Color-code defines the dependence of different UPR branches and in italic their role and function.