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. 2018 Apr 9;9:326. doi: 10.3389/fphar.2018.00326

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Copyright © 2018 Lin, Ho, Cheng, Chiou, Yen, Chang, Lee and Hsiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LC53 inhibited the nuclear phosphorylated p65 translocation in LPS-stimulated microglial BV2 cells. Microglial BV2 cells were pretreated with the vehicle (DMSO), LC53 (10 μM) or parthenolide (10 μM) and stimulated with LPS (150 ng/ml) for 30 min. Phosphorylated p65 levels in both cytoplasm and nuclear of BV2 microglia were examined using Western blot. The detections of α-tubulin and lamin B1 were used as the internal control for cytoplasm and nucleus (n = 4). R, resting; V, vehicle (DMSO); Par, parthenolide; p-p65, phosphorylated p65. ^###p < 0.001 compared with the resting group; ^∗∗∗p < 0.001 compared with the LPS-stimulated group treated with vehicle.