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. 2018 Apr 12;17:1533033818767936. doi: 10.1177/1533033818767936

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Comparison of real-time NIR images of 3 OSCC-xenografted tumors in mice using the ICG-labeled anti-podoplanin antibody and a handheld detection device (PDE). A, Real-time NIR images (dark field) of 3 OSCC intracutaneous (short arrows) and subcutaneous tumors (long arrows) in mice (n = 4). Arrowheads indicate the liver. B, Quantitative analysis of NIR fluorescence intensity of UMSCC-81, HSC-3, and Ca9-22 intracutaneous and subcutaneous tumors. Bar = standard deviation. * P < .05 compared with the UMSCC-81 tumors. AU indicates arbitrary units; NIR, near-infrared; NS, not significant; PDE, photodynamic eye; OSCC, oral squamous cell carcinoma.