Table 4.
Pharmacokinetic Parameters of Vortioxetine in the Elderly Population (Study 2)
| Administration of Single 10‐mg Dose | ||
|---|---|---|
| Elderly Men | Elderly Womenb | |
| Characteristic, Arithmetic Mean (SD)a | (n = 8) | (n = 7) |
| Cmax (ng/mL) | 4.2 (0.9) | 4.6 (0.6) |
| Tmax (h) | 6.0 (5‐8) | 6.0 (6‐10) |
| AUC0–inf (ng·h/mL) | 378.0 (170.0) | 305.0 (80.2) |
| T1/2 (h) | 85.2 (29.8) | 63.5 (10.7) |
| Fe0–120 (%) | 0.0 (0.0) | 0.0 (0.0) |
AE, adverse event; AUC0–inf, area under the plasma concentration–time curve from time 0 to infinity; Cmax, maximum observed plasma concentration; Fe0–120, fraction excreted from 0 to 120 hours; SD, standard deviation; T1/2, terminal elimination half‐life; Tmax, time to reach Cmax.
a
Tmax is presented as median (min‐max).
b
One woman was excluded from the pharmacokinetic analysis set because she experienced an AE (vomiting) after study drug administration.