Figure 3.

An overview of Muc2 biosynthesis in epithelial goblet cells. Monomeric Muc2 core polypeptide is synthesized in the rough endoplasmic reticulum (ER) (1), before dimerization (2) and transport into the cis‐golgi compartment where O‐linked glycosylation is initiated through the addition of GalNAc to either serine/threonine residues, (3) and extensive post‐translational modifications occur as the dimers pass through the golgi compartment. (4) At the trans‐golgi compartment, mucin dimers multimerize into large complexes (5) before becoming packaged into secretory granules prior to secretion (6)