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. 2018 Mar 4;40(4):e12517. doi: 10.1111/pim.12517

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© 2018 The Authors. Parasite Immunology Published by John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Mucosal alterations during intestinal helminth infections. After helminth infection tuft cells will secrete IL‐25, which leads to the production of type 2 cytokines, predominately ILC2 derived IL‐13, which together with Th2 derived IL‐13 leads to goblet cell (GC) and tuft cell hyperplasia and changes in mucin production (Muc2 and Muc5ac) and mucin properties (glycosylation). These alterations change the properties of the mucus barrier to aid host protection against intestinal nematode infection