Figure 6. Alignment of the human dopamine receptor 2 (DRD₂) with zebrafish (Danio rerio), coelacanth (Latimeria chalumnae) and spotted gar (Lepisosteus oculatus) dopamine receptor 2l (DRD_2l).

Shaded regions denote transmembrane domains according to UniProt. Dopamine binding sites, agonist and antagonist binding sites were predicted with theoretical and computational techniques (Yashar et al., 2004) and experimental evidence (Shi & Javitch, 2002) . Amino acids in the third intracellular loop conferring G protein subunit Gαi specificity (Senogles et al., 2004) are indicated by orange asterisks.