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. 2018 Mar 23;175(9):1419–1438. doi: 10.1111/bph.14132

Figure 3.

Figure 3

ACKR3 and CXCR3 activation by CXCL11 N‐loop variants. (A) CXCR3 activation by CXCL11 WT and N‐loop variants monitored in HEK293 cells through intracellular calcium release using FLIPR 4 Calcium Flux kit dye. (B and C) Comparison of β‐arrestin‐2 recruitment to CXCR3 (B) and ACKR3 (C) induced by CXCL11WT and N‐loop variants monitored in HEK293 cells by BRET using receptor‐YFP fusion constructs and β‐arrestin‐2‐Rluc. Each experiment was performed five times, and the data shown are means ± SEM.