Table 1.
ED50 values (with 95% CL) of 2‐BFI or CR4056 alone or in combination with pharmacological manipulations of monoaminergic mechanisms
| Dose | V | 0.01 | 0.032 | 0.1 | 0.32 | 1.0 | 3.2 | 10 |
|---|---|---|---|---|---|---|---|---|
| BFI/CCI | ||||||||
| Fluoxetine | 7.06 (5.92, 8.44) | – | – | – | – | – | 4.25 (3.43, 5.30)a | 2.37 (1.93, 2.91)a |
| Desipramine | 7.05 (5.36, 9.26) | – | – | – | – | – | 4.53 (3.29, 6.25) | 2.31 (1.48, 3.59)a |
| GBR12909 | 6.68 (5.37, 8.31) | – | – | – | – | – | – | 6.27 (5.57, 7.06) |
| WAY100635 | 7.64 (6.17, 9.48) | 8.08 (7.19, 9.07) | 15.62 (11.62, 21.00)b | 19.24 (13.38, 27.68)b | – | – | – | – |
| MDL100907 | 5.90 (4.40, 7.92) | 5.88 (4.58, 7.55) | 12.27 (9.11, 16.53)b | 19.18 (13.53, 27.20)b | – | – | – | – |
| SB242084 | 6.53 (4.91, 8.66) | – | – | – | 6.34 (5.09, 7.90) | 6.18 (4.64, 8.24) | – | – |
| WB4101 | 8.86 (7.27, 10.80) | – | – | – | 7.43 (5.46, 10.13) | 13.72 (11.17, 16.86)b | 22.21 (18.63, 26.49)b | – |
| Yohimbine | 6.84 (5.82, 8.05) | – | – | – | – | 6.65 (5.23, 8.45) | 6.63 (4.98, 8.84) | – |
| SCH23390 | 6.43 (4.46, 9.29) | – | 6.47 (4.51, 9.30) | 5.85 (4.16, 8.21) | – | – | – | – |
| Raclopride | 6.50 (4.77, 8.86) | – | – | – | 6.93 (4.77, 10.07) | 6.09 (4.28, 8.68) | – | – |
| CR4056/CCI | ||||||||
| WAY100635 | 10.33 (8.80, 12.12) | 11.47 (9.27, 14.19) | 22.16 (18.42, 26.66)b | 40.25 (32.47, 49.88)b | – | – | – | – |
| MDL100907 | 10.49 (7.72, 14.25) | 13.81 (10.45, 18.23) | 25.19 (17.70, 35.86)b | 45.45 (31.12, 66.37)b | – | – | – | – |
| SB242084 | 10.85 (7.69, 15.30) | – | – | – | 10.94 (8.34, 14.35) | 12.45(8.89, 17.42) | – | – |
| WB4101 | 11.71 (9.12, 15.04) | – | – | – | 12.67 (10.26, 15.66) | 24.44 (18.34, 32.57)b | 43.72 (35.36, 54.07)b | – |
| Yohimbine | 12.81 (9.91, 16.57) | – | – | – | – | 11.11 (9.11, 13.54) | 11.47 (8.09, 16.29) | – |
| SCH23390 | 11.10 (8.29, 14.96) | – | 10.88 (7.18, 16.49) | 11.00 (8.10, 14.96) | – | – | – | – |
| Raclopride | 12.65 (9.50, 16.84) | – | – | – | 12.95 (9.50, 17.66) | 9.27 (6.79, 12.67) | – | – |
| BFI/CFA | ||||||||
| WAY100635 | 8.46 (7.29, 9.81) | 8.46 (7.05, 10.15) | 15.34 (13.63, 17.27)b | 24.99 (21.15, 29.52)b | – | – | – | – |
| MDL100907 | 8.35 (7.11, 9.82) | 8.23 (6.75, 10.04) | 14.69 (11.51, 18.74)b | 19.99 (14.91, 26.81)b | – | – | – | – |
| SB242084 | 8.33 (7.13, 9.74) | – | – | – | 8.49 (7.31, 9.87) | 8.52 (6.84, 10.60) | – | – |
| WB4101 | 8.59 (6.80, 10.86) | – | – | – | 8.40 (6.93, 10.18) | 12.47 (10.85, 14.34) | 21.68 (17.98, 26.14)b | – |
| Yohimbine | 7.78 (6.76, 8.96) | – | – | – | – | 6.75 (5.14, 8.88) | 7.86 (6.88, 8.97) | – |
| SCH23390 | 7.79 (6.72, 9.02) | – | 6.38 (4.44, 9.16) | 8.29 (7.19, 9.55) | – | – | – | – |
| Raclopride | 7.68 (6.40, 9.20) | – | – | – | 8.64 (7.57, 9.86) | 7.37 (6.03, 9.00) | – | – |
a
Combination ED50 lower than control.
b
Combination ED50 higher than control.
The above indicates that CLs do not overlap with those of the control values (2‐BFI or CR4056 alone).