Figure 2.

CRF₂ receptor deficiency does not influence sociability or social recognition memory under basal drug‐naïve conditions. (A) Sociability and (C) SNP ratio (%) displayed by drug‐naïve wild‐type and CRF₂−/− mice repeatedly tested (tests 1 to 3) once a week in the three‐chamber task. A 0, 2 or 4 h ITI was pseudorandomly applied between the sociability and the SNP test. The ratio was calculated as the percentage of time spent investigating the wire cage containing the unfamiliar or the novel mouse over the total time spent investigating the two wire cages during the sociability or the SNP test respectively. (B, D) Total entries made into the two side compartments of the three‐chamber apparatus during the sociability or the SNP test. Values represent mean ± SEM. ^# P < 0.05 versus wild‐type mice, genotype effect. ^## P < 0.05 versus test 1, repeated measure effect. ^### P < 0.05 versus 0 and 4 h ITI, repeated measure effect.