Figure 2.
Deciding when to lower the dose based on leukemic burden and BCR‐ABL1 transcript levels. BCR‐ABL1 transcript levels are monitored by real‐time quantitative polymerase chain reaction. The relationship to transcript levels and possible outcomes is indicated. CCyR indicates complete cytogenetic response; IS, International Scale; MMR, major molecular response; MR4.5, molecular response with 4.5‐log reduction of BCR‐ABL1 transcripts. Reproduced without modification from Morotti A, Fava C, Saglio G. Milestones and monitoring. Curr Hematol Malig Rep. 2015;10:167‐172. ©The Authors 2015. Published with open access at http://Springerlink.com under the terms of Creative Commons Attribution 4.0 International License (CC BY 4.0; https://creativecommons.org/licenses/by/4.0/).19