Figure 2.

Morphology and cellular composition of the Car9 ^−/− and WT gastric mucosa from newborn to advanced age. Distribution of (a) H⁺/K⁺‐ATPase‐positive parietal cells and (b) PAS‐positive mucous cells in the gastric glands over time. Upper panel: WT mucosa, lower panel: Car9 ^−/− mucosa. (c) Total cell number per gland, (d) H⁺/K⁺‐ATPase‐positive cell number per gland and (e) the ratio of H⁺/K⁺‐ATPase‐positive/total cells per gland. A significant decrease in parietal cell number per gland/decrease in the parietal cell/total cell ratio was observed from 3 months of age. (f) Electron micrograph of a parietal cell at the base of a gland of a 9 month old Car9 ^−/− mouse displays intact morphological feature. mv microvilli, mi mitochondria. n = 6, *P < 0.05.